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Influenza virus-like particles composed of conserved influenza proteins and GPI-anchored CCL28/GM-CSF fusion proteins enhance protective immunity against homologous and heterologous viruses 期刊论文

编号：

f3b64542-d112-40f6-8ac9-600034e2faf3
作者：

Liu, Jing^[1,2,3];Ren, Zhiguang^[4,5];Wang, Hongmei^[7];Zhao, Yongkun^[3];Wilker, Peter R.^[6];Yu, Zhijun^[8];Sun, Weiyang^[3];Wang, Tiecheng^[3];Feng, Na^[3];Li, Yuanguo^[3];Wang, Hualei(王化磊)^[3]Ji, Xianliang^[3];Li, Nan^[3];Yang, Songtao(杨松涛)^[3,9]He, Hongbin^[7];Qin, Chuan^[1,2];Gao, Yuwei(高玉伟)*^[3,9]Xia, Xianzhu(夏咸柱)*^[1,2,3,9]
语种：

英文
期刊：

INTERNATIONAL IMMUNOPHARMACOLOGY ISSN：1567-5769 2018 年 63 卷 (119 - 128) ; OCT
疾病分类：

流行性感冒其它感染性疾病
关键词：

Influenza cVLPs vaccine GPI-CCL28 GPI-GM-CSF Broad-spectrum Intranasal administration
摘要：

Influenza viruses cause significant morbidity and mortality and pose a substantial threat to public health. Vaccination represents the principle means of preventing influenza virus infection. Current vaccine approaches are hindered by the need to routinely reformulate vaccine compositions in an effort to account for the progressive antigenic changes that occur as influenza viruses circulate in the human population. In this study, we evaluated chimeric virus-like particle (cVLP) vaccines containing conserved elements of influenza proteins (HL5M2e (HA stem gene with 5M2e gene inserted) and NP), with or without glycosylphosphatidylinositol-anchored CCL28 (GPI-CCL28) and/or GM-CSF (GPI-GM-CSF) fusion proteins as molecular adjuvants. cVLPs elicited strong humoral and cellular immune responses against homologous and heterologous viruses, and improved survival following lethal challenge with both homologous and heterologous viruses. Inclusion of GPI-anchored adjuvants in cVLP vaccines augmented the generation of influenza-specific humoral and cellular immune responses in mice in comparison to the non-adjuvanted cVLP vaccines. VLPs containing GPI-anchored adjuvants reduced morbidity and improved survival to lethal challenge with homologous and heterologous influenza viruses. This work suggests that VLP vaccines incorporating conserved influenza virus proteins and GPI-anchored molecular adjuvants may serve as a platform for a broadly protective "universal" influenza vaccine.
推荐引用方式
GB/T 7714：

Liu Jing,Ren Zhiguang,Wang Hongmei, et al. Influenza virus-like particles composed of conserved influenza proteins and GPI-anchored CCL28/GM-CSF fusion proteins enhance protective immunity against homologous and heterologous viruses [J].INTERNATIONAL IMMUNOPHARMACOLOGY,2018,63:119-128.
APA：

Liu Jing,Ren Zhiguang,Wang Hongmei,Zhao Yongkun,&Xia Xianzhu.(2018).Influenza virus-like particles composed of conserved influenza proteins and GPI-anchored CCL28/GM-CSF fusion proteins enhance protective immunity against homologous and heterologous viruses .INTERNATIONAL IMMUNOPHARMACOLOGY,63:119-128.
MLA：

Liu Jing, et al. "Influenza virus-like particles composed of conserved influenza proteins and GPI-anchored CCL28/GM-CSF fusion proteins enhance protective immunity against homologous and heterologous viruses" .INTERNATIONAL IMMUNOPHARMACOLOGY 63(2018):119-128.
数据来源自科睿唯安Web of Science核心合集
入库时间：

2021/11/7 8:51:42
更新时间：

2021/11/7 8:51:42

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