The epidemiologic effects of Zika virus (ZIKV) sexual transmission in virus-endemic countries remain unclear. We conducted a 2-level, linear mixed-effects logistic regression analysis by using a recently acquired population-based ZIKV and chikungunya virus (CHIKV) serologic dataset obtained from persons residing in Northeast Brazil (n = 2,070 participants). We adjusted mathematical models for housing type and age of participants; the models indicated a significantly higher likelihood of ZIKV seropositivity among persons engaged in a sexual relationship within the same household (odds ratio 1.25 [95% CI 1.00-1.55]; p = 0.047), regardless of their partner''s ZIKV serostatus, and among participants with a ZIKV-seropositive sex partner within the same household (odds ratio 1.54 [95% CI1.18-2.01]; p = 0.002). CHIKV was also modeled as a control; no sex-associated effects were observed for CHIKV serology. Inclusion of ZIKV sexual transmission in prevention and control strategies is urgently needed, particularly in ZIKV-endemic regions.
[1]Texas A&M Univ, College Stn, TX USA.
[2]Fundacao Getulio Vargas, Rio De Janeiro, Brazil.
[3]Fundacao Oswaldo Cruz, Inst Aggeu Magalhaes, Recife, Brazil.
[4]Colorado Sch Publ Hlth, Aurora, CO USA.
[5]Heidelberg Univ Hosp, Heidelberg, Germany.
[6]Univ Pittsburgh, Pittsburgh, PA USA.
[7]Colorado State Univ, Ft Collins, CO USA.
(8.0+极速模式)