首页 / 院系成果 / 成果详情页

Research priorities towards precision antibiotic therapy to improve patient care 期刊论文

编号：

EEE736163F7087C7D672387228B1F29C
作者：

Bulman, Zackery P.^[1];Wicha, Sebastian G.^[2];Nielsen, Elisabet, I^[3];Lenhard, Justin R.^[5];Nation, Roger L.^[6]Theuretzbacher, Ursula^[10];Derendorf, Hartmut^[11];Tangden, Thomas^[4];Zeitlinger, Markus^[12];Landersdorfer, Cornelia B.^[7];Bulitta, Juergen B.^[13];Friberg, Lena E.^[3];Li, Jian^[8,9]Tsuji, Brian T.^[14];
语种：

英文
期刊：

LANCET MICROBE ISSN：2666-5247 2022 年 3 卷 10 期 (E795 - E802) ; OCT
摘要：

Antibiotic resistance presents an incessant threat to our drug armamentarium that necessitates novel approaches to therapy. Over the past several decades, investigation of pharmacokinetic and pharmacodynamic (PKPD) principles has substantially improved our understanding of the relationships between the antibiotic, pathogen, and infected patient. However, crucial gaps in our understanding of the pharmacology of antibacterials and their optimal use in the care of patients continue to exist; simply attaining antibiotic exposures that are considered adequate based on traditional targets can still result in treatment being unsuccessful and resistance proliferation for some infections. It is this salient paradox that points to key future directions for research in antibiotic therapeutics. This Personal View discusses six priority areas for antibiotic pharmacology research: (1) antibiotic-pathogen interactions, (2) antibiotic targets for combination therapy, (3) mechanistic models that describe the time-course of treatment response, (4) understanding and modelling of host response to infection, (5) personalised medicine through therapeutic drug management, and (6) application of these principles to support development of novel therapies. Innovative approaches that enhance our understanding of antibiotic pharmacology and facilitate more accurate predictions of treatment success, coupled with traditional pharmacology research, can be applied at the population level and to individual patients to improve outcomes.
推荐引用方式
GB/T 7714：

Bulman Zackery P.,Wicha Sebastian G.,Nielsen Elisabet I, et al. Research priorities towards precision antibiotic therapy to improve patient care [J].LANCET MICROBE,2022,3(10):E795-E802.
APA：

Bulman Zackery P.,Wicha Sebastian G.,Nielsen Elisabet I,Lenhard Justin R.,&Tsuji Brian T..(2022).Research priorities towards precision antibiotic therapy to improve patient care .LANCET MICROBE,3(10):E795-E802.
MLA：

Bulman Zackery P., et al. "Research priorities towards precision antibiotic therapy to improve patient care" .LANCET MICROBE 3,10(2022):E795-E802.
数据来源自科睿唯安Web of Science核心合集
入库时间：

2022/12/1 12:26:22
更新时间：

2022/12/1 12:26:22

浏览次数：21  下载次数：0

分享到：

浏览次数：21

下载次数：0

打印次数：0