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Impact of respiratory pathogens detection by a rapid multiplex polymerase chain reaction assay on the management of community- acquired pneumonia for children at the paediatric emergency department. A randomized controlled trial, the Optimization of Pneumonia Acute Care (OPTIPAC) study 期刊论文

编号：

CFCDE42A4F6361AEB5C87570FE758C0F
作者：

Cantais, Aymeric^[1,2] Pillet, Sylvie^[2,3] Rigaill, Josselin^[2,3] Angoulvant, Francois^[4] GrasLeGuen, Christele^[5] Cros, Pierrick^[6] Thuiller, Charlotte^[1] Molly, Claudine^[1] Tripodi, Louise^[1] Desbree, Aurelie^[1] Annino, Nadine^[1] Verhoeven, Paul^[2,3] Carricajo, Anne^[2,3] Bourlet, Thomas^[2,3] Chapelle, Celine^[7] Claudet, Isabelle^[8] Garcin, Arnauld^[7] Izopet, Jacques^[9] Mory, Olivier^[1] Pozzetto, Bruno^[2,3]
语种：

英文
期刊：

CLINICAL MICROBIOLOGY AND INFECTION ISSN：1198-743X 2025 年 31 卷 1 期 (64 - 70) ; JAN
关键词：

Antibiotic stewardship Emergency Paediatric PCR multiplex Pneumonia
摘要：

Objectives: The pathogen of community-acquired pneumonia (CAP) in children is typically uncertain during initial treatment, leading to systematic empiric antibiotic use. This study investigates if having rapid multiplex PCR results in the emergency department (ED) improves empiric treatment. Methods: OPTIPAC, a French multicentre study (2016-2018), enrolled patients consulting for CAP at the paediatric ED in 11 centres. Patients were randomized to either receive a multiplex PCR test plus usual care or usual care alone and followed for 15 days. The primary outcome was the appropriateness of initial antimicrobial management, determined by a blinded committee. Results: Of the 499 randomized patients, 248 were tested with the multiplex PCR. Appropriateness of the antibiotic treatment was higher in the PCR group (168/245, 68.6% vs. 120/249, 48.2%; Relative risk 1.42 [1.22-1.66]; p < 0.0001), chiefly by reducing unnecessary antibiotics in viral pneumonia (RR 3.29 [2.20-4.90]). No adverse events were identified. Discussion: The multiplex PCR assay result at the ED improves paediatric CAP''s antimicrobial stewardship, by both reducing antibiotic prescriptions and enhancing treatment appropriateness. (c) 2024 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. Allrights are reserved, including those for text and data mining, AI training, and similar technologies.
推荐引用方式
GB/T 7714：

Cantais Aymeric,Pillet Sylvie,Rigaill Josselin, et al. Impact of respiratory pathogens detection by a rapid multiplex polymerase chain reaction assay on the management of community- acquired pneumonia for children at the paediatric emergency department. A randomized controlled trial, the Optimization of Pneumonia Acute Care (OPTIPAC) study [J].CLINICAL MICROBIOLOGY AND INFECTION,2025,31(1):64-70.
APA：

Cantais Aymeric,Pillet Sylvie,Rigaill Josselin,Angoulvant Francois,&Pozzetto Bruno.(2025).Impact of respiratory pathogens detection by a rapid multiplex polymerase chain reaction assay on the management of community- acquired pneumonia for children at the paediatric emergency department. A randomized controlled trial, the Optimization of Pneumonia Acute Care (OPTIPAC) study .CLINICAL MICROBIOLOGY AND INFECTION,31(1):64-70.
MLA：

Cantais Aymeric, et al. "Impact of respiratory pathogens detection by a rapid multiplex polymerase chain reaction assay on the management of community- acquired pneumonia for children at the paediatric emergency department. A randomized controlled trial, the Optimization of Pneumonia Acute Care (OPTIPAC) study" .CLINICAL MICROBIOLOGY AND INFECTION 31,1(2025):64-70.
数据来源自科睿唯安Web of Science核心合集
入库时间：

2025/3/11 15:51:38
更新时间：

2025/3/11 15:51:38

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