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Measures of Longitudinal Immune Dysfunction and Risk of AIDS and Non-AIDS Defining Malignancies in Antiretroviral Treated People With Human Immunodeficiency Virus (HIV) 期刊论文

编号：

CB07406E25EE2A635C10B02362093C64
作者：

Chammartin, Frederique^[1,2];Mocroft, Amanda^[3,4]Egle, Alexander^[5];Zangerle, Robert^[6];Smith, Colette^[7];Mussini, Cristina^[8];Wit, Ferdinand^[9];Vehreschild, Joerg Janne^[10];d''Arminio Monforte, Antonella^[11];Castagna, Antonella^[12];Bailly, Laurent^[13];Bogner, Johannes^[14];de Wit, Stephane^[15];Matulionyte, Raimonda^[16];Law, Matthew^[17];Svedhem, Veronica^[18,19];Tallada, Joan^[20];Garges, Harmony P.^[21];Marongiu, Andrea^[22];Borges, alvaro H.^[3,23];Jaschinski, Nadine^[3];Neesgaard, Bastian^[3];Ryom, Lene^[3,24];Bucher, Heiner C.;
语种：

英文
期刊：

CLINICAL INFECTIOUS DISEASES ISSN：1058-4838 2023 年 ; 2023 DEC 13
疾病分类：

艾滋病
关键词：

CD4:CD8 ratio HIV infection malignancy observational study antiretroviral therapy
摘要：

Background. Human immunodeficiency virus (HIV) infection leads to chronic immune activation/inflammation that can persist in virally suppressed persons on fully active antiretroviral therapy (ART) and increase risk of malignancies. The prognostic role of low CD4:CD8 ratio and elevated CD8 cell counts on the risk of cancer remains unclear.Methods. We investigated the association of CD4:CD8 ratio on the hazard of non-AIDS defining malignancy (NADM), AIDS-defining malignancy (ADM) and most frequent group of cancers in ART-treated people with HIV (PWH) with a CD4 and CD8 cell counts and viral load measurements at baseline. We developed Cox proportional hazard models with adjustment for known confounders of cancer risk and time-dependent cumulative and lagged exposures of CD4:CD8 ratio to account for time-evolving risk factors and avoid reverse causality.Results. CD4:CD8 ratios below 0.5, compared to above 1.0, were independently associated with a 12-month time-lagged higher risk of ADM and infection-related malignancies (adjusted hazard ratio 2.61 [95% confidence interval {CI }1.10-6.19] and 2.03 [95% CI 1.24-3.33], respectively). CD4 cell counts below 350 cells/mu L were associated with an increased risk of NADMs and ADMs, as did infection, smoking, and body mass index-related malignancies.Conclusions. In ART-treated PWH low CD4:CD8 ratios were associated with ADM and infection-related cancers independently from CD4 and CD8 cell counts and may alert clinicians for cancer screening and prevention of NADM.
推荐引用方式
GB/T 7714：

Chammartin Frederique,Mocroft Amanda,Egle Alexander, et al. Measures of Longitudinal Immune Dysfunction and Risk of AIDS and Non-AIDS Defining Malignancies in Antiretroviral Treated People With Human Immunodeficiency Virus (HIV) [J].CLINICAL INFECTIOUS DISEASES,2023.
APA：

Chammartin Frederique,Mocroft Amanda,Egle Alexander,Zangerle Robert,&Bucher Heiner C..(2023).Measures of Longitudinal Immune Dysfunction and Risk of AIDS and Non-AIDS Defining Malignancies in Antiretroviral Treated People With Human Immunodeficiency Virus (HIV) .CLINICAL INFECTIOUS DISEASES.
MLA：

Chammartin Frederique, et al. "Measures of Longitudinal Immune Dysfunction and Risk of AIDS and Non-AIDS Defining Malignancies in Antiretroviral Treated People With Human Immunodeficiency Virus (HIV)" .CLINICAL INFECTIOUS DISEASES(2023).
数据来源自科睿唯安Web of Science核心合集
入库时间：

2024/1/23 22:35:03
更新时间：

2024/1/23 22:35:03

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