Sexually transmitted Chlamydia trachomatis infections remain common globally and most frequently are asymptomatic. The 2025 European C. trachomatis guideline provides up-to-date guidance regarding indications for testing and treatment of C. trachomatis infections. It includes advice on urogenital and extragenital C. trachomatis testing including the use of self-collected specimens; recommendation to use only validated NAATs for diagnosis; and recommendation to treat all C. trachomatis infections with doxycycline as first line in preference to single-dose azithromycin regimens. The absence of evidence and limited value of broad screening in asymptomatic populations for C. trachomatis infections is also discussed.
[1]Northern & Western Hlth & Social Care Trusts, Londonderry, North Ireland.
[2]Maastricht Univ, Care & Publ Hlth Res Inst CAPHRI, Dept Hlth Promot, Maastricht, Netherlands.
[3]South Limburg Publ Hlth Serv, Dept Sexual Hlth Infect Dis & Environm Hlth, Living Lab Publ Hlth Mosa, Heerlen, Netherlands.
[4]Maastricht Univ, Care & Publ Hlth Res Inst CAPHRI, Dept Social Med, Maastricht, Netherlands.
[5]Maastricht Univ Med Ctr MUMC, Care & Publ Hlth Res Inst CAPHRI, Dept Med Microbiol Infect Dis & Infect Prevent, Dutch Natl Chlamydia Trachomatis Reference Lab, Maastricht, Netherlands.
[6]Inst Trop Med, Antwerp, Belgium.
[7]Orebro Univ, Fac Med & Hlth, WHO Collaborating Ctr Gonorrhoea & Other Sexually, Natl Reference Lab Sexually Transmitted Infect,Dep, SE-70182 Orebro, Sweden.
[8]Univ Coll London UCL, Inst Global Hlth, London, England.
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