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Design of Cryptococcus neoformans multi-epitope vaccine based on immunoinformatics method 期刊论文

编号：

B94C48C7CF1687CB734AD3F06557BFB1
作者：

Zhou, Ziyou^[1,2,3,4];Zhu, Fei^[1,2,3,4];Ma, Shiyang^[1,2,3,4]Tan, Caixia^[5,6];Yang, Hang^[1,2,3,4];Zhang, Peipei^[1,2,3,4];Xu, Yizhong^[1,2,3,4];Qin, Rongliu^[1,2,3,4];Luo, Yuying^[1,2,3,4];Chen, Jie^[1,2,3,4]Pan, Pinhua(潘频华)^[1,2,3,4]
语种：

英文
期刊：

MEDICAL MYCOLOGY ISSN：1369-3786 2024 年 62 卷 8 期 ; AUG 26
关键词：

Crytococcus neoformans multi-epitope vaccine molecular docking molecular dynamics (MD) simulation immunoinformatics
摘要：

Cryptococcus neoformans is a widely distributed opportunistic pathogenic fungus. While C. neoformans commonly infects immunocompromised individuals, it can also affect those who are immunocompetent. Transmission of C. neoformans primarily occurs through the respiratory tract, leading to the development of meningitis. The mortality rate of Cryptococcal meningitis is high, and treatment options are limited. Cryptococcus neoformans infections pose a significant public health threat and currently lack targeted and effective response strategies. This study aimed to screen T lymphocyte (cytotoxic T lymphocyte and helper T lymphocyte) and B lymphocyte epitopes derived from four C. neoformans antigens and develop two multi-epitope vaccines by combining them with various adjuvants. Molecular docking results demonstrated that the vaccines bind stably to Toll-like receptor 4 ( and induce innate immunity. The credibility of the molecular docking results was validated through subsequent molecular dynamics simulations. Furthermore, the results of immune simulation analyses underscored the multi-epitope vaccine''s capability to effectively induce robust humoral and cellular immune responses within the host organism. These two vaccines have demonstrated theoretical efficacy against C. neoformans infection as indicated by computer analysis. Nevertheless, additional experimental validation is essential to substantiate the protective efficacy of the vaccines. A multi-epitope Cryptococcus neoformans vaccine covering the most common A and D phenotypes was designed using bioinformatics methods.
推荐引用方式
GB/T 7714：

Zhou Ziyou,Zhu Fei,Ma Shiyang, et al. Design of Cryptococcus neoformans multi-epitope vaccine based on immunoinformatics method [J].MEDICAL MYCOLOGY,2024,62(8).
APA：

Zhou Ziyou,Zhu Fei,Ma Shiyang,Tan Caixia,&Pan Pinhua.(2024).Design of Cryptococcus neoformans multi-epitope vaccine based on immunoinformatics method .MEDICAL MYCOLOGY,62(8).
MLA：

Zhou Ziyou, et al. "Design of Cryptococcus neoformans multi-epitope vaccine based on immunoinformatics method" .MEDICAL MYCOLOGY 62,8(2024).
数据来源自科睿唯安Web of Science核心合集
入库时间：

2024/10/25 9:30:31
更新时间：

2024/10/25 9:30:31

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