We describe the novel use of oral chloramphenicol for treatment-resistant Mycoplasma genitalium (M. genitalium) infection in a 20-year-old heterosexual cisgender male presenting with recurrent symptomatic non-gonococcal urethritis. M. genitalium urethritis is an increasingly common clinical conundrum in sexual health clinics and in cases of second-line treatment failure (such as moxifloxacin), UK and international guidelines struggle to make recommendations for third-line treatments. As shown in our case, the evidence base for third-line treatments is lacking, with poor success rates, and may be poorly tolerated. Here we demonstrate the novel use of a well-tolerated oral antimicrobial, chloramphenicol, resulting in rapid microbiological and clinical cure in treatment-resistant M. genitalium urethritis.
[1]Chelsea & Westminster Hosp NHS Fdn Trust, Directorate HIV & Sexual Hlth, London, England.
[2]Chelsea & Westminster Hosp NHS Fdn Trust, London, England.
[3]Chelsea & Westminster Hosp NHS Fdn Trust, Clin Infect Dept, London, England.
[4]Imperial Coll Healthcare NHS Trust, North West London Pathol, London, England.
[5]Chelsea & Westminster Hosp NHS Fdn Trust, Directorate HIV & Sexual Hlth, London SW10 9NH, England.
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