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Whole genome sequencing of multidrug-resistant Proteus mirabilis strain PM1162 recovered from a urinary tract infection in China 期刊论文

编号：

976D4B5B0EFF7576CFCC59A2EC8E938F
作者：

Yang, Jing^[1] Shan, Ge^[2] Yu, Guangchao^[3] Wei, Jie^[4] Zhang, Qinghuan^[4] Su, Wen^[5] Lin, Qiuping^[5] Zheng, Zhixiong^[5] Wu, Guangliang^[6] Li, Guangtian^[7] Chang, Qing^[8] Yuan, Hong^[1] He, Yanju^[1] Chen, Yanling^[1] Zhang, Yi^[1] Huang, Haile^[1] Hu, Wan^[1] Song, Rongqing^[1] Weng, Yuqing^[1] Li, Xiaobin^[5] Liu, Shengming^[9]
语种：

英文
期刊：

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE ISSN：2213-7165 2023 年 33 卷 (44 - 50) ; JUN
关键词：

Proteus mirabilis Multidrug resistance Whole genome sequencing Antibiotic resistance gene Genetic context
摘要：

Objectives: Proteus mirabilis is an important opportunistic Gram-negative pathogen. This study reports the whole genome sequence of multidrug-resistant (MDR) P. mirabilis PM1162 and explores its antibiotic resistance genes (ARGs) and their genetic environments. Methods: P. mirabilis PM1162 was isolated from a urinary tract infection in China. Antimicrobial suscep-tibility was determined, and whole genome sequencing (WGS) was performed. ARGs, insertion sequence (IS) elements, and prophages were identified using ResFinder, ISfinder, and PHASTER software, respec-tively. Sequence comparisons and map generation were performed using BLAST and Easyfig, respectively. Results: On its chromosome, P. mirabilis PM1162 harboured 15 ARGs, including cat, tet(J), blaCTX-M-14 (three copies), aph(3'')-Ia, qnrB4, blaDHA-1, qacE, sul1, armA, msr(E), mph(E), aadA1, and dfrA1. We focused our analysis on the four related MDR regions: (1) genetic contexts associated with bla CTX-M-14; (2) the prophage containing blaDHA-1, qnrB4, and aph(3'')-Ia; (3) genetic environments associated with mph(E), msr(E), armA, sul, and qacE; and (4) the class II integron harbouring dfrA1, sat2, and aadA1. Conclusion: This study reported the whole genome sequence of MDR P. mirabilis PM1162 and the genetic context of its ARGs. This comprehensive genomic analysis of MDR P. mirabilis PM1162 provides a deeper understanding of its MDR mechanism and elucidates the horizontal spread of its ARGs, thus providing a basis for the containment and treatment of the bacteria. (c) 2023 The Authors. Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
推荐引用方式
GB/T 7714：

Yang Jing,Shan Ge,Yu Guangchao, et al. Whole genome sequencing of multidrug-resistant Proteus mirabilis strain PM1162 recovered from a urinary tract infection in China [J].JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE,2023,33:44-50.
APA：

Yang Jing,Shan Ge,Yu Guangchao,Wei Jie,&Liu Shengming.(2023).Whole genome sequencing of multidrug-resistant Proteus mirabilis strain PM1162 recovered from a urinary tract infection in China .JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE,33:44-50.
MLA：

Yang Jing, et al. "Whole genome sequencing of multidrug-resistant Proteus mirabilis strain PM1162 recovered from a urinary tract infection in China" .JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE 33(2023):44-50.
数据来源自科睿唯安Web of Science核心合集
入库时间：

2023/5/30 15:25:31
更新时间：

2023/5/30 15:25:31

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