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Subclinical Myocardial Fibrosis in South African Youth With HIV: Results From the CTAAC-Heart Study 期刊论文

编号：

95E62A1BCFC970C47F39BBC039CE884E
作者：

Jao, Jennifer^[1]Zar, Heather J.^[2,3]Kahts, Morne^[4,5];Jermy, Stephen^[5,6];Egan, Daniel^[4,5];Nyathi, Mothabisi N.^[7];AsafuAgyei, Nana Akua^[2,3];Legbedze, Justine^[8];Carkeek, Emma^[2,3];Jele, Nomawethu^[2,3];Mautsa, Tafadzwa^[2,3];Bonner, Lauren Balmert^[9];McComsey, Grace A.^[10]Feinstein, Matthew^[9,11]Kurland, Irwin J.^[12];Myer, Landon^[7]Ntusi, Ntobeko A. B.^[4,5,13]
语种：

英文
期刊：

OPEN FORUM INFECTIOUS DISEASES ISSN：2328-8957 2024 年 11 卷 10 期 ; OCT 16
疾病分类：

艾滋病
关键词：

antiretroviral myocardial fibrosis myocardial magnetic resonance imaging perinatally acquired HIV youth with HIV
摘要：

Background Few data exist on myocardial fibrosis and inflammation in youth with HIV. Methods We performed cardiovascular magnetic resonance (CMR) on a cross section of South African youth: youth with perinatally acquired HIV (YPHIV) undergoing antiretroviral therapy (ART), youth with nonperinatally acquired HIV (YNPHIV) receiving ART, and youth without HIV. Quantile regression models were fit to assess the association between HIV status and CMR outcomes: subclinical fibrosis (late gadolinium enhancement [LGE] mass and fraction, native T1, extracellular volume) and inflammation (native T1, T2 mapping). Results Of 464 youth, 287 were YPHIV, 87 were YNPHIV, and 90 were HIV seronegative. The median age was 16 years (range, 11-24). LGE mass was higher in YPHIV and YNPHIV than in youth who were HIV seronegative (1.85 vs 2.00 vs 1.41 g, respectively), as was fraction (5.8% vs 6.4% vs 4.5%); native T1 was highest in YNPHIV. In adjusted analyses, when compared with youth with HIV seronegativity, YPHIV and YNPHIV exhibited higher LGE mass (beta = 0.468, P = .001; beta = 0.544, P = .002) and LGE fraction (beta = 1.587, P < .001; beta = 1.781, P < .001). CMR outcomes were similar between YPHIV and YNPHIV. Conclusions Despite ART use, YPHIV and YNPHIV appear to have higher subclinical myocardial fibrosis than youth who are HIV seronegative and healthy adults in South Africa and may benefit from early screening/monitoring for cardiovascular disease.
推荐引用方式
GB/T 7714：

Jao Jennifer,Zar Heather J.,Kahts Morne, et al. Subclinical Myocardial Fibrosis in South African Youth With HIV: Results From the CTAAC-Heart Study [J].OPEN FORUM INFECTIOUS DISEASES,2024,11(10).
APA：

Jao Jennifer,Zar Heather J.,Kahts Morne,Jermy Stephen,&Ntusi Ntobeko A. B..(2024).Subclinical Myocardial Fibrosis in South African Youth With HIV: Results From the CTAAC-Heart Study .OPEN FORUM INFECTIOUS DISEASES,11(10).
MLA：

Jao Jennifer, et al. "Subclinical Myocardial Fibrosis in South African Youth With HIV: Results From the CTAAC-Heart Study" .OPEN FORUM INFECTIOUS DISEASES 11,10(2024).
数据来源自科睿唯安Web of Science核心合集
入库时间：

2024/12/9 14:27:46
更新时间：

2024/12/9 14:27:46

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