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Clinical features-based machine learning models to separate sexually transmitted infections from other skin diagnoses 期刊论文

编号：

9570025ECDC08ADC1CB69707774EA1EC
作者：

Soe, Nyi Nyi^[1,2];Latt, Phyu Mon^[1,2];Yu, Zhen^[2,4];Lee, David^[1];Kim, ChamMill^[3];Tran, Daniel^[3];Ong, Jason J.^[1,2]Ge, Zongyuan^[4]Fairley, Christopher K.^[1,2]Zhang, Lei(张磊)^[1,2,5]
语种：

英文
期刊：

JOURNAL OF INFECTION ISSN：0163-4453 2024 年 88 卷 4 期 ; APR
关键词：

Sexually transmitted infections Machine learning Electronic health records
摘要：

Introduction: Many sexual health services are overwhelmed and cannot cater for all the individuals who present with sexually transmitted infections (STIs). Digital health software that separates STIs from nonSTIs could improve the efficiency of clinical services. We developed and evaluated a machine learning model that predicts whether patients have an STI based on their clinical features. Methods: We manually extracted 25 demographic features and clinical features from 1315 clinical records in the electronic health record system at Melbourne Sexual Health Center. We examined 16 machine learning models to predict a binary outcome of an STI or a non-STI diagnosis. We evaluated the models'' performance with the area under the ROC curve (AUC), accuracy and F1 -scores. Results: Our study included 1315 consultations, of which 36.8% (484/1315) were diagnosed with STIs and 63.2% (831/1315) had non-STI conditions. The study population predominantly consisted of heterosexual men (49.5%, 651/1315), followed by gay, bisexual and other men who have sex with men (GBMSM) (25.7%), women (21.6%) and unknown gender (3.2%). The median age was 31 years (intra-quartile range (IQR) 26-39). The top 5 performing models were CatBoost (AUC 0.912), Random Forest (AUC 0.917), LightGBM (AUC 0.907), Gradient Boosting (AUC 0.905) and XGBoost (AUC 0.900). The best model, CatBoost, achieved an accuracy of 0.837, sensitivity of 0.776, specificity of 0.831, precision of 0.782 and F1 -score of 0.778. The key important features were lesion duration, type of skin lesions, age, gender, history of skin disorders, number of lesions, dysuria duration, anorectal pain and itchiness. Conclusions: Our best model demonstrates a reasonable performance in distinguishing STIs from non-STIs. However, to be clinically useful, more detailed information such as clinical images, may be required to reach sufficient accuracy. (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
推荐引用方式
GB/T 7714：

Soe Nyi Nyi,Latt Phyu Mon,Yu Zhen, et al. Clinical features-based machine learning models to separate sexually transmitted infections from other skin diagnoses [J].JOURNAL OF INFECTION,2024,88(4).
APA：

Soe Nyi Nyi,Latt Phyu Mon,Yu Zhen,Lee David,&Zhang Lei.(2024).Clinical features-based machine learning models to separate sexually transmitted infections from other skin diagnoses .JOURNAL OF INFECTION,88(4).
MLA：

Soe Nyi Nyi, et al. "Clinical features-based machine learning models to separate sexually transmitted infections from other skin diagnoses" .JOURNAL OF INFECTION 88,4(2024).
数据来源自科睿唯安Web of Science核心合集
入库时间：

2024/10/24 21:33:39
更新时间：

2024/10/24 21:33:39

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