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Comparative Efficacy of Continuous Ceftazidime Infusion vs. Intermittent Bolus against In Vitro Ceftazidime-Susceptible and -Resistant Pseudomonas aeruginosa Biofilm 期刊论文

编号：

94B1BB3DB339B695102556B611759F6D
作者：

El Haj, Cristina^[1,2];Agusti, Eugenia^[1,2];Benavent, Eva^[1,2];SoldevilaBoixader, Laura^[1,2];RigoBonnin, Raul^[2,3];Tubau, Fe^[4,5];Torrejon, Benjamin^[6];Esteban, Jaime^[7,8]Murillo, Oscar^[1,2,8]
语种：

英文
期刊：

ANTIBIOTICS-BASEL ISSN：2079-6382 2024 年 13 卷 4 期 ; APR
关键词：

beta-lactams PK/PD P. aeruginosa biofilm foreign-body infection
摘要：

Background: As the anti-biofilm pharmacokinetic/pharmacodynamic (PK/PD) properties of antibiotics are not well-defined, we have evaluated the PK/PD indices for different regimens of ceftazidime (CAZ; with/without colistin) against Pseudomonas aeruginosa biofilm. Methods: We have used the Center for Disease Control and Prevention Biofilm Reactor with two susceptible (PAO1 and HUB-PAS) and one resistant (HUB-XDR) strains of P. aeruginosa. The regimens were CAZ monotherapies (mimicking a human dose of 2 g/8 h, CAZ-IB; 6 g/daily as continuous infusion at 50 mg/L, CAZ-CI50; and 9 g/daily at 70 mg/L, CAZ-CI70) and CAZ-colistin combinations. Efficacy was correlated with the CAZ PK/PD parameters. Results: CAZ-CI70 was the most effective monotherapy against CAZ-susceptible strains (Delta log CFU/mL 54-0 h = -4.15 +/- 0.59 and -3.05 +/- 0.5 for HUB-PAS and PAO1, respectively; p <= 0.007 vs. other monotherapies), and adding colistin improved the efficacy over CAZ monotherapy. CAZ monotherapies were ineffective against the HUB-XDR strain, and CAZ-CI50 plus colistin achieved higher efficacy than CAZ-IB with colistin. The PK/PD index that correlated best with anti-biofilm efficacy was fAUC(0-24h)/MIC (r(2) = 0.78). Conclusions: CAZ exhibited dose-dependent anti-biofilm killing against P. aeruginosa, which was better explained by the fAUC(0-24h)/MIC index. CAZ-CI provided benefits compared to CAZ-IB, particularly when using higher doses and together with colistin. CAZ monotherapies were ineffective against the CAZ-resistant strain, independently of the optimized strategy and only CAZ-CI plus colistin appeared useful for clinical practice.
推荐引用方式
GB/T 7714：

El Haj Cristina,Agusti Eugenia,Benavent Eva, et al. Comparative Efficacy of Continuous Ceftazidime Infusion vs. Intermittent Bolus against In Vitro Ceftazidime-Susceptible and -Resistant Pseudomonas aeruginosa Biofilm [J].ANTIBIOTICS-BASEL,2024,13(4).
APA：

El Haj Cristina,Agusti Eugenia,Benavent Eva,Soldevila-Boixader Laura,&Murillo Oscar.(2024).Comparative Efficacy of Continuous Ceftazidime Infusion vs. Intermittent Bolus against In Vitro Ceftazidime-Susceptible and -Resistant Pseudomonas aeruginosa Biofilm .ANTIBIOTICS-BASEL,13(4).
MLA：

El Haj Cristina, et al. "Comparative Efficacy of Continuous Ceftazidime Infusion vs. Intermittent Bolus against In Vitro Ceftazidime-Susceptible and -Resistant Pseudomonas aeruginosa Biofilm" .ANTIBIOTICS-BASEL 13,4(2024).
数据来源自科睿唯安Web of Science核心合集
入库时间：

2024/6/5 17:07:03
更新时间：

2024/6/5 17:07:03

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