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Durability of multi-drug antiretroviral therapy (mega-ART) in treatment-experienced people with HIV in the ARCA database 期刊论文

编号：

8B3B305834531E68167FD80310014DAF
作者：

Labate, Laura^[1] Rossetti, Barbara^[2] Russo, Chiara^[1] Cassol, Chiara^[2] Bottanelli, Martina^[3,4] Papaioannu Borjesson, Rebecka^[3,4] Rancan, Laura^[5,6] Bracchitta, Fiorenza^[7] Graziani, Lucia^[8] Tilli, Marta^[8] Malcontenti, Costanza^[9] Mora, Sara^[10] Bezenchek, Antonia^[11,12] Shallvari, Adrian^[11,12] Zazzi, Maurizio^[5] Di Biagio, Antonio^[1,13]
语种：

英文
期刊：

ANTIVIRAL THERAPY ISSN：1359-6535 2025 年 30 卷 2 期 ; APR
疾病分类：

艾滋病
关键词：

antiretroviral treatment HIV genotypic resistance test treatment-experienced deep salvage
摘要：

Objective To explore the durability of multi-drug antiretroviral regimens in treatment-experienced PWH. Design This retrospective observational study including PWH who started mega-ART regimens between 1 January 2009 and 31 December 2019, selected from the ARCA cohort. Methods Time-dependent events were analysed by Kaplan-Meier methods, while Cox regression models were used to define the predictors of mega-ART discontinuation. Results A total of 1,514 ART-experienced PWH were included. Over a median follow-up of 47 weeks (IQR 15-127), 1,299 (83%) mega-ART were interrupted, with an incidence of 85.62 per 100 person-years of follow-up. In the multivariable analysis, predictors of higher risk of mega-ART discontinuation were a higher number of antiretroviral drugs included in baseline regimens (aHR 1.206, CI 95% 1.016-1.431, p = .032) and a higher baseline HIV RNA log10 (aHR 1.113, CI 95% 1.048-1.181, p < .001); otherwise, shorter duration of previous ART was associated with a lower risk of discontinuation (aHR 0.982, CI 95% 0.965-0.999, p = .037). When mega-ART was stopped, 299 PWH (23%) had HIV RNA levels above 50 copies/ml, 16/299 (1%) had HIV RNA levels >50 copies/ml but less than 200 copies/ml, 792 PWH (61%) had HIV RNA levels below 50 copies/ml, and 208 PWH (16%) had an undetermined HIV RNA load. Conclusions Mega-ART was characterized by limited durability and poor virological success.
推荐引用方式
GB/T 7714：

Labate Laura,Rossetti Barbara,Russo Chiara, et al. Durability of multi-drug antiretroviral therapy (mega-ART) in treatment-experienced people with HIV in the ARCA database [J].ANTIVIRAL THERAPY,2025,30(2).
APA：

Labate Laura,Rossetti Barbara,Russo Chiara,Cassol Chiara,&Di Biagio Antonio.(2025).Durability of multi-drug antiretroviral therapy (mega-ART) in treatment-experienced people with HIV in the ARCA database .ANTIVIRAL THERAPY,30(2).
MLA：

Labate Laura, et al. "Durability of multi-drug antiretroviral therapy (mega-ART) in treatment-experienced people with HIV in the ARCA database" .ANTIVIRAL THERAPY 30,2(2025).
数据来源自科睿唯安Web of Science核心合集
入库时间：

2025/5/14 12:08:28
更新时间：

2025/5/14 12:08:28

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