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Viruses harness Yxxempty set motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target 期刊论文

编号：

86e1cafa-55c7-417f-991b-800d0d42d242
作者：

Yuan, Shuofeng^[1,2,3,4];Chu, Hin^[1,2,3,4];Huang, Jingjing^[2];Zhao, Xiaoyu^[2];Ye, ZiWei^[2];Lai, PokMan^[2];Wen, Lei^[2];Cai, JianPiao^[2];Mo, Yufei^[5];Cao, Jianli^[2];Liang, Ronghui^[2];Poon, Vincent KwokMan^[2];Sze, KongHung^[1,2,3];Zhou, Jie^[1,2,3,4];To, Kelvin KaiWang(杜启泓)^[1,2,3,4,5]Chen, Zhiwei(陈志伟)^[1,2,3,6]Chen, Honglin(陈鸿霖)^[1,2,3,4]Jin, DongYan^[7];Chan, Jasper FukWoo(陈福和)*^{[1,2,3,4,5,8]}Yuen, KwokYung(袁国勇)^{[1,2,3,4,5,8]}
语种：

英文
期刊：

SCIENCE ADVANCES ISSN：2375-2548 2020 年 6 卷 35 期 ; AUG
疾病分类：

其它感染性疾病
摘要：

Targeting a universal host protein exploited by most viruses would be a game-changing strategy that offers broad-spectrum solution and rapid pandemic control including the current COVID-19. Here, we found a common Yxxempty set-motif of multiple viruses that exploits host AP2M1 for intracellular trafficking. A library chemical, N-(p-amylcinnamoyl)anthranilic acid (ACA), was identified to interrupt AP2M1 -virus interaction and exhibit potent antiviral efficacy against a number of viruses in vitro and in vivo, including the influenza A viruses (IAVs), Zika virus (ZIKV), human immunodeficiency virus, and coronaviruses including MERS-CoV and SARS-CoV-2. Yxxempty set mutation, AP2M1 depletion, or disruption by ACA causes incorrect localization of viral proteins, which is exemplified by the failure of nuclear import of IAV nucleoprotein and diminished endoplasmic reticulum localization of ZIKV-NS3 and enterovirus-A71-2C proteins, thereby suppressing viral replication. Our study reveals an evolutionarily conserved mechanism of protein-protein interaction between host and virus that can serve as a broad-spectrum antiviral target.
推荐引用方式
GB/T 7714：

Yuan Shuofeng,Chu Hin,Huang Jingjing, et al. Viruses harness Yxxempty set motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target [J].SCIENCE ADVANCES,2020,6(35).
APA：

Yuan Shuofeng,Chu Hin,Huang Jingjing,Zhao Xiaoyu,&Yuen Kwok-Yung.(2020).Viruses harness Yxxempty set motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target .SCIENCE ADVANCES,6(35).
MLA：

Yuan Shuofeng, et al. "Viruses harness Yxxempty set motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target" .SCIENCE ADVANCES 6,35(2020).
数据来源自科睿唯安Web of Science核心合集
入库时间：

2021/11/7 18:39:31
更新时间：

2021/11/7 18:39:31

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