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Patterns of peri-gestational weight change among women living with HIV in Nigeria receiving dolutegravir compared to alternative antiretroviral regimens: a retrospective cohort study 期刊论文

编号：

83009819D1A8829D2B6D0D31CFEB6907
作者：

Al Naimi, Ammar^[1,2,3] Chang, Charlotte^[1] Rawizza, Holly^[1,4] Olaifa, Oluwaseun^[5] Ogunsola, Olabanjo^[5] Okonkwo, Prosper^[5] Kanki, Phyllis^[1]
语种：

英文
期刊：

AIDS RESEARCH AND THERAPY ISSN：1742-6405 2025 年 22 卷 1 期 ; MAR 24
疾病分类：

艾滋病
关键词：

Dolutegravir DTG HIV Gestational weight Weight change
摘要：

BackgroundWeight change for women living with HIV (WLWH) who receive dolutegravir (DTG) is understudied around pregnancy. The aim of this study was to investigate the direction and magnitude of weight change among WLWH pre-, during, and post-gestation based on DTG exposure history.MethodsThis retrospective cohort study evaluated adult pregnant WLWH receiving antenatal care between 2016 and 2022 at two clinics in Nigeria and followed them over three 9-month periods (pregestational, antenatal, and postgestational). Patients were stratified into three DTG exposure groups for each follow-up period: non-DTG, DTG-switch, and DTG. Three mixed effects models with random intercepts and slopes were utilized to assess the association between DTG and weight. Sensitivity analysis was conducted using binomial DTG exposure with starting time.ResultsThe study included 2386 women, 851 (35.7%) of whom used DTG at some point. Average maternal weight was 63.8 +/- 12.7 kg, 67.0 +/- 13.1 kg, and 64.5 +/- 12.7 kg during the pregestational, antenatal, and postgestational period. The weight difference in kg for DTG and DTG-switch compared to other ARTs were 0.06 (-1.66, 1.79) and -2.11 (-5.33, 1.11) pregestational, -0.613 (-2.14, 0.92) and 1.21 (-0.80, 3.21) antepartum, and 2.64 (0.37, 4.91) and 0.89 (-1.40, 3.18) postgestational. The antenatal slope (beta) for DTG exposure and initiation time was 0.01 (0.001, 0.02) kg/day.ConclusionsDTG therapy is associated with more rapid weight gain during pregnancy without significantly affecting the total weight gained. Moreover, retained weight postgestation is higher in women on DTG. Therefore, they could face higher future metabolic and cardiovascular risks.
推荐引用方式
GB/T 7714：

Al Naimi Ammar,Chang Charlotte,Rawizza Holly, et al. Patterns of peri-gestational weight change among women living with HIV in Nigeria receiving dolutegravir compared to alternative antiretroviral regimens: a retrospective cohort study [J].AIDS RESEARCH AND THERAPY,2025,22(1).
APA：

Al Naimi Ammar,Chang Charlotte,Rawizza Holly,Olaifa Oluwaseun,&Kanki Phyllis.(2025).Patterns of peri-gestational weight change among women living with HIV in Nigeria receiving dolutegravir compared to alternative antiretroviral regimens: a retrospective cohort study .AIDS RESEARCH AND THERAPY,22(1).
MLA：

Al Naimi Ammar, et al. "Patterns of peri-gestational weight change among women living with HIV in Nigeria receiving dolutegravir compared to alternative antiretroviral regimens: a retrospective cohort study" .AIDS RESEARCH AND THERAPY 22,1(2025).
数据来源自科睿唯安Web of Science核心合集
入库时间：

2025/4/6 16:42:26
更新时间：

2025/4/6 16:42:26

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