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Optimising antiretroviral therapy through a proactive treatment algorithm: a cost-effective strategy in Dutch healthcare for people with HIV 期刊论文

编号：

7F59F6C308790EA6437F9839739C7317
作者：

Oosterhof, P.^[1,2] van Luin, M.^[3] Grintjes, K.^[4] van der Meche, N.^[5] van Crevel, R. Brinkman, K. Burger, D. M.^[2]
语种：

英文
期刊：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY ISSN：0305-7453 2025 年 ; 2025 APR 12
疾病分类：

艾滋病
摘要：

Background A wide range of effective antiretroviral therapy (ART) regimens with favourable side effects are available. More than 70% of HIV care costs in the Netherlands are attributed to ART. We developed an ART algorithm to proactively switch virologically suppressed individuals to a more cost-effective HIV treatment.Methods This prospective study implemented our ART algorithm in two large Dutch HIV clinics, where a pharmacist screened ART regimens for 1 year. Individuals were considered suitable for a switch if their current ART exceeded 600 per month, considering renal function and/or tubular toxicity, hepatitis B status, and resistance history. If eligible, advice with a switch proposal was recorded in the patient file. The objective was to investigate the acceptance of the proposal and the effect of proactive switching on the total costs of ARTs.Findings Of 1596 people living with HIV, 840 (52.6%) were eligible. Prescribers accepted 81.1% of the switch proposals, and 84.9% of eligible individuals agreed to the proposed switch. Ultimately, 558 individuals accepted the new ART regimen proposal, with doravirine/tenofovir disoproxil fumarate/lamuvidine (DOR/TDF/3TC) being the most prescribed (61.6%). The switch led to significant cost savings, reducing annual ART expenditure from 10 923 to 8580 per eligible individual, totalling almost 2 million (-21.4%) in savings annually.Interpretation Our ART algorithm demonstrated high acceptance by prescribers and people with HIV, leading to substantial cost savings. The algorithm can be easily implemented in other HIV clinics to offer even more significant cost savings to Dutch healthcare payers.
推荐引用方式
GB/T 7714：

Oosterhof P.,van Luin M.,Grintjes K., et al. Optimising antiretroviral therapy through a proactive treatment algorithm: a cost-effective strategy in Dutch healthcare for people with HIV [J].JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,2025.
APA：

Oosterhof P.,van Luin M.,Grintjes K.,van der Meche N.,&Burger D. M..(2025).Optimising antiretroviral therapy through a proactive treatment algorithm: a cost-effective strategy in Dutch healthcare for people with HIV .JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY.
MLA：

Oosterhof P., et al. "Optimising antiretroviral therapy through a proactive treatment algorithm: a cost-effective strategy in Dutch healthcare for people with HIV" .JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY(2025).
数据来源自科睿唯安Web of Science核心合集
入库时间：

2025/5/14 12:10:04
更新时间：

2025/5/14 12:10:04

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