首页 / 院系成果 / 成果详情页

Antibiotic Resistance in Helicobacter pylori Isolates from Northwestern and Central Romania Detected by Culture-Based and PCR-Based Methods 期刊论文

编号：

78524323179B6E16BB973807EF89C5CE
作者：

Costache, Carmen^[1,2] Colosi, Horatiu Alexandru^[3] Grad, Simona^[2,4] Pastiu, Anamaria Ioana^[5] Militaru, Mariela^[6,7] Hadarean, Anca Paula^[7] Toc, Dan Alexandru^[1] Neculicioiu, Vlad Sever^[1] Baciu, Alina Mihaela^[1] Opris, Razvan Vlad^[1] Dumitrascu, Dan Lucian^[2,4] Colosi, Ioana Alina^[1,8]
语种：

英文
期刊：

ANTIBIOTICS-BASEL ISSN：2079-6382 2023 年 12 卷 12 期 ; DEC
关键词：

Helicobacter pylori antibiotic resistance ETEST (R) GenoType HelicoDr Romania
摘要：

Little evidence has been published regarding the antimicrobial resistance patterns of Helicobacter pylori (H. pylori) strains in Northwestern and Central Romania. The aim of this study was to determine the antibiotic resistance pattern of H. pylori isolates from gastric biopsies collected from patients living in Romania using ETEST (R) and GenoType HelicoDR. Gastric biopsies were obtained from 148 adult patients, 87 women and 61 men, the majority (131 patients) from Northwestern and Central Romania. Sixty-nine H. pylori strains were detected by both culture and PCR; sixty-three biopsies were negative by both techniques; one biopsy was positive by culture but negative by PCR; and fifteen biopsies were negative by culture but positive by PCR. Primary resistance against clarithromycin, fluoroquinolones, and metronidazole was found in 16.7%, 11.1%, and 13.3% of strains, respectively. No primary resistance has been detected against amoxicillin, tetracycline, and rifampicin. Secondary resistance against clarithromycin, fluoroquinolones, metronidazole, amoxicillin, tetracycline, and rifampicin was found in 75.8%, 30.3%, 65.5%, 1.8%, 1.8%, and 7.3% of the strains, respectively. The most frequent clarithromycin-resistant genotype detected by GenoType HelicoDR was A2147G (62.3%). Concordances between ETEST (R) and PCR for clarithromycin and fluoroquinolones were 85.5% and 78.3%, respectively. Further investigation of H. pylori resistance should be conducted to ensure proper eradication schemes.
推荐引用方式
GB/T 7714：

Costache Carmen,Colosi Horatiu Alexandru,Grad Simona, et al. Antibiotic Resistance in Helicobacter pylori Isolates from Northwestern and Central Romania Detected by Culture-Based and PCR-Based Methods [J].ANTIBIOTICS-BASEL,2023,12(12).
APA：

Costache Carmen,Colosi Horatiu Alexandru,Grad Simona,Pastiu Anamaria Ioana,&Colosi Ioana Alina.(2023).Antibiotic Resistance in Helicobacter pylori Isolates from Northwestern and Central Romania Detected by Culture-Based and PCR-Based Methods .ANTIBIOTICS-BASEL,12(12).
MLA：

Costache Carmen, et al. "Antibiotic Resistance in Helicobacter pylori Isolates from Northwestern and Central Romania Detected by Culture-Based and PCR-Based Methods" .ANTIBIOTICS-BASEL 12,12(2023).
数据来源自科睿唯安Web of Science核心合集
入库时间：

2024/1/23 22:47:54
更新时间：

2024/1/23 22:47:54

浏览次数：32  下载次数：0

分享到：

浏览次数：32

下载次数：0

打印次数：0