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Clinical features and immune memory of breakthrough infection in children after age-appropriate 13-valent pneumococcal conjugate vaccination in Taiwan 期刊论文

编号：

698BEC6AB8FBDDC06DCCD89A902B709C
作者：

Chen, ChihHo^[1];Hsu, MeiHua^[2];OuYang, MeiChen^[1];Yin, ChenTing^[1];Li, HsinChieh^[2];Su, LinHui^[2]Cheng, ShuShen^[3];Chiu, ChengHsun*^[2,4]
语种：

英文
期刊：

INFECTION ISSN：0300-8126 2024 年 ; 2024 NOV 5
关键词：

Immunogenicity Memory B cells Breakthrough infection PCV13
摘要：

Purpose As certain vaccine serotypes are still circulating within the community during the PCV13 era, we aimed to delineate the clinical features and assess the immunity following breakthrough infections in children. Methods 101 PCVs-vaccinated children < 18 years with culture confirmed PCV13 serotype breakthrough infection (25/101, invasive pneumococcal disease [IPD]) was identified in Taiwan in 2015-2019. Immunoglobulin G (IgG) antibody levels, IgM+ memory B cells (MBCs), and isotype-switched immunoglobulin (sIg+) MBC specific to serotypes 3, 14, 19 A were assessed prior to and one month after an additional PCV13 booster in 9 patients. A cohort of 89 previously vaccinated, healthy children were enrolled as controls. Results The majority (88%) of the breakthrough infection occurred in children under 7 years old. Infection by serotypes 3 and 19 A increased in children aged 5-17 years in 2018-2019. The pre-booster serotype 3- and 19 A-specific IgG in both children with breakthrough infection and controls were lower than the IPD protective thresholds (2.83 g/mL for 3; 1.00 mu g/mL for 19 A). Breakthrough infected children showed higher geometric mean ratio in serotype-specific IgG, IgM+ MBCs and sIg+ MBC after an additional PCV13 booster, compared to the controls. Conclusions Most breakthrough infections occurred in previously healthy preschool-aged children, but such infections may still occur in school-aged children due to waning immunity. Breakthrough infections may also enhance the anamnestic response elicited by PCV13.
推荐引用方式
GB/T 7714：

Chen Chih-Ho,Hsu Mei-Hua,Ou-Yang Mei-Chen, et al. Clinical features and immune memory of breakthrough infection in children after age-appropriate 13-valent pneumococcal conjugate vaccination in Taiwan [J].INFECTION,2024.
APA：

Chen Chih-Ho,Hsu Mei-Hua,Ou-Yang Mei-Chen,Yin Chen-Ting,&Chiu Cheng-Hsun.(2024).Clinical features and immune memory of breakthrough infection in children after age-appropriate 13-valent pneumococcal conjugate vaccination in Taiwan .INFECTION.
MLA：

Chen Chih-Ho, et al. "Clinical features and immune memory of breakthrough infection in children after age-appropriate 13-valent pneumococcal conjugate vaccination in Taiwan" .INFECTION(2024).
数据来源自科睿唯安Web of Science核心合集
入库时间：

2024/12/9 15:01:21
更新时间：

2024/12/9 15:01:21

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