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Rat hepatitis E virus (Rocahepevirus ratti) in people living with HIV 期刊论文

编号：

639B9E1898E7A8724A50D3B0DB1F0B2E
作者：

CasaresJimenez, Maria^[1];RiveroJuarez, Antonio^[1,2,12]LopezLopez, Pedro^[1,2];Montes, Maria Luisa^[2,3];NavarroSoler, Roser^[4];Peraire, Joaquin^[2,5];Espinosa, Nuria^[6];AlemanValls, Maria Remedios^[7];GarciaGarcia, Transito^[8];CaballeroGomez, Javier^[1,2,9];CoronaMata, Diana^[1,2];PerezValero, Ignacio^[1,2];Ulrich, Rainer G.^[10,11];Rivero, Antonio^[1,2]
语种：

英文
期刊：

EMERGING MICROBES & INFECTIONS ISSN：2222-1751 2024 年 13 卷 1 期 ; DEC 31
疾病分类：

艾滋病
关键词：

Hepatitis E rat hepatitis E virus acute hepatitis HIV Zoonoses public health
摘要：

Rat hepatitis E virus (ratHEV; species Rocahepevirus ratti) is considered a newly emerging cause of acute hepatitis of zoonotic origin. ratHEV infection of people living with HIV (PLWH) might portend a worse, as with hepatitis E virus (HEV; species Paslahepevirus balayani), and consequently this group may constitute a high-risk population. We aimed to evaluate the prevalence of ratHEV by measuring viral RNA and specific IgG antibodies in a large Spanish cohort of PLWH. Multicentre study conducted in Spain evaluating PLWHIV included in the Spanish AIDS Research Network (CoRIS). Patients were evaluated for ratHEV infection using PCR at baseline and anti-ratHEV IgG by dot blot analysis to evaluate exposure to ratHEV strains. Patients with detectable ratHEV RNA were followed-up to evaluate persistence of viremia and IgG seroconversion. Eight-hundred and forty-two individuals were tested. A total of 9 individuals showed specific IgG antibodies against ratHEV, supposing a prevalence of 1.1 (95% CI; 0.5%-2.1%). Of these, only one was reactive to HEV IgG antibodies by ELISA. One sample was positive for ratHEV RNA (prevalence of infection: 0.1%; 95% CI: 0.08%-0.7%). The case was a man who had sex with men exhibiting a slightly increased alanine transaminase level (49 IU/L) as only biochemical alteration. In the follow-up, the patients showed undetectable ratHEV RNA and seroconversion to specific ratHEV IgG antibodies. Our study shows that ratHEV is geographical broadly distributed in Spain, representing a potential zoonotic threat.
推荐引用方式
GB/T 7714：

Casares-Jimenez Maria,Rivero-Juarez Antonio,Lopez-Lopez Pedro, et al. Rat hepatitis E virus (Rocahepevirus ratti) in people living with HIV [J].EMERGING MICROBES & INFECTIONS,2024,13(1).
APA：

Casares-Jimenez Maria,Rivero-Juarez Antonio,Lopez-Lopez Pedro,Montes Maria Luisa,&Rivero Antonio.(2024).Rat hepatitis E virus (Rocahepevirus ratti) in people living with HIV .EMERGING MICROBES & INFECTIONS,13(1).
MLA：

Casares-Jimenez Maria, et al. "Rat hepatitis E virus (Rocahepevirus ratti) in people living with HIV" .EMERGING MICROBES & INFECTIONS 13,1(2024).
数据来源自科睿唯安Web of Science核心合集
入库时间：

2024/1/23 22:43:53
更新时间：

2024/1/23 22:43:53

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