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Definition, Burden, and Predictors of HIV-Associated Wasting and Low Weight in the OPERA(& REG;) Cohort 期刊论文

编号：

497C5D0E20FF1CFDE2334DF3DCF4CA4E
作者：

Wohlfeiler, Michael B.^[1] Weber, Rachel Palmieri^[2,8] Brunet, Laurence^[2] Siddiqui, Javeed^[3] Harbour, Michael^[4] Phillips, Amy L.^[4] Hayward, Brooke^[4,7] Fusco, Jennifer S.^[2] Hsu, Ricky K. K.^[5,6] Fusco, Gregory P.^[2]
语种：

英文
期刊：

AIDS RESEARCH AND HUMAN RETROVIRUSES ISSN：0889-2229 2023 年 ; 2023 AUG 18
疾病分类：

艾滋病
关键词：

comorbidity HIV wasting syndrome incidence prevalence weight loss
摘要：

We aimed to describe the prevalence, incidence, and predictors of HIV-associated wasting (HIVAW)/low weight among people with HIV (PWH) in the United States. We conducted an observational, clinical cohort analysis, utilizing prospectively collected electronic health record data obtained from the Observational Pharmaco-Epidemiology Research & Analysis (OPERA(& REG;)) cohort. HIVAW/low weight included a wasting or low body-mass index (BMI)/underweight diagnosis (ICD codes and title search) or BMI <20 kg/m(2). Prevalence was estimated among adult PWH in care from 2012 to 2015 and 2016 to 2020. Incidence from January 1, 2016, to October 31, 2021, was estimated using univariate Poisson regression among eligible PWH without prior HIVAW/low weight. Demographic and clinical predictors of incident HIVAW/low weight were included in multivariable logistic regression models, stratified by antiretroviral therapy (ART) experience. The period prevalence of HIVAW/low weight was 12% in both 2012-2015 and 2016-2020. Among 67,119 PWH without any prior HIVAW/low weight, 7% experienced incident HIVAW/low weight a median 64 months from HIV diagnosis. In multivariable regression models, similar predictor patterns were observed among ART-naive and ART-experienced PWH without any prior HIVAW/low weight: lower odds of HIVAW/low weight with older age, female sex, Black race, and Hispanic ethnicity and higher odds with Medicaid. Notably, there was a dose-response relationship between increasing Veterans Aging Cohort Study Mortality Index scores and incident HIVAW/low weight in both groups. Wasting/low weight remains a challenge for PWH and may be underappreciated by providers. Advanced HIV and comorbidities significantly predict incident HIVAW/low weight. Increasing awareness of HIVAW, especially among frailer PWH, could improve the care of affected PWH.
推荐引用方式
GB/T 7714：

Wohlfeiler Michael B.,Weber Rachel Palmieri,Brunet Laurence, et al. Definition, Burden, and Predictors of HIV-Associated Wasting and Low Weight in the OPERA(& REG;) Cohort [J].AIDS RESEARCH AND HUMAN RETROVIRUSES,2023.
APA：

Wohlfeiler Michael B.,Weber Rachel Palmieri,Brunet Laurence,Siddiqui Javeed,&Fusco Gregory P..(2023).Definition, Burden, and Predictors of HIV-Associated Wasting and Low Weight in the OPERA(& REG;) Cohort .AIDS RESEARCH AND HUMAN RETROVIRUSES.
MLA：

Wohlfeiler Michael B., et al. "Definition, Burden, and Predictors of HIV-Associated Wasting and Low Weight in the OPERA(& REG;) Cohort" .AIDS RESEARCH AND HUMAN RETROVIRUSES(2023).
数据来源自科睿唯安Web of Science核心合集
入库时间：

2023/10/10 15:10:40
更新时间：

2023/10/10 15:10:40

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