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Changes in Clinical Features and Severity of COVID-19 with the Emergence of Omicron Variants: A Shift Towards a Common Disease 期刊论文

编号：

3EFFCA0B079832603D8DDE3919F6689A
作者：

Kawamura, Saori^[1];Yamaguchi, Fumihiro^[1];Kusakado, Rui^[1];Go, Yoshihiro^[1];Nohmi, Shiho^[1];Yoshizaki, Chinatsu^[1];Yoshida, Yuki^[1];Izumizaki, Kensuke^[1];Saito, Yuichiro^[1];Kobayashi, Hitoshi^[1];Hirata, Kento^[1];Miyo, Kenta^[1];Kondo, Chika^[1];Kanzaki, Mamiko^[1];Ding, Yize^[1];Yokoe, Takuya^[1]Kobayashi, Sei^[2];Suzuki, Hiroshi^[3]
语种：

英文
期刊：

INFECTION AND DRUG RESISTANCE ISSN：1178-6973 2024 年 17 卷 (5595 - 5603)
疾病分类：

传染性非典型肺炎、新型冠状病毒肺炎
关键词：

severe acute respiratory syndrome coronavirus-2 coronavirus disease 2019 Omicron variants C-reactive protein
摘要：

Background: The emergence of the Omicron variant of severe acute respiratory syndrome coronavirus-2 has significantly altered the clinical features and severity of coronavirus disease 2019 (COVID-19). Objective: This study aims to evaluate whether the clinical factors that previously predicted COVID-19 remain valid following the emergence of the Omicron variant. Methods: This cross-sectional study was conducted at Showa University Fujigaoka Hospital from April 2022 to March 2023. A total of 576 patients with suspected COVID-19 were included, of which 258 (44.8%) were diagnosed with COVID-19 based on real-time reverse-transcription polymerase chain reaction tests. Clinical data were collected retrospectively, and multivariate logistic regression was used to analyze factors associated with a COVID-19 diagnosis. Results: Of the 258 patients diagnosed with COVID-19, 60% had mild disease, and the overall severity was lower than in previous reports prior to the emergence of the Omicron variant. In the multivariate analysis, only C-reactive protein (CRP) levels were significantly associated with COVID-19 (odds ratio, 0.3164; 95% confidence interval, 0.2077-0.4819), while factors such as age, sex, body mass index, lactate dehydrogenase, and comorbidities were not significantly associated. Non-COVID-19 cases were primarily bacterial infections, accounting for 57.2% of the non-COVID-19 diagnoses. Mortality rates did not differ significantly between the COVID-19 and non-COVID-19 groups. Conclusion: The clinical characteristics of COVID-19 have become less distinct since the emergence of the Omicron variant, with CRP being the primary marker associated with a COVID-19 diagnosis. As COVID-19 continues to transition towards a more common infectious disease, distinguishing it will become increasingly challenging.
推荐引用方式
GB/T 7714：

Kawamura Saori,Yamaguchi Fumihiro,Kusakado Rui, et al. Changes in Clinical Features and Severity of COVID-19 with the Emergence of Omicron Variants: A Shift Towards a Common Disease [J].INFECTION AND DRUG RESISTANCE,2024,17:5595-5603.
APA：

Kawamura Saori,Yamaguchi Fumihiro,Kusakado Rui,Go Yoshihiro,&Suzuki Hiroshi.(2024).Changes in Clinical Features and Severity of COVID-19 with the Emergence of Omicron Variants: A Shift Towards a Common Disease .INFECTION AND DRUG RESISTANCE,17:5595-5603.
MLA：

Kawamura Saori, et al. "Changes in Clinical Features and Severity of COVID-19 with the Emergence of Omicron Variants: A Shift Towards a Common Disease" .INFECTION AND DRUG RESISTANCE 17(2024):5595-5603.
数据来源自科睿唯安Web of Science核心合集
入库时间：

2025/1/3 17:49:08
更新时间：

2025/1/3 17:49:08

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