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Association Between Vitamin D Insufficiency and Impaired Bone Density Among Adolescents With Perinatally Acquired HIV Infection 期刊论文

编号：

3C354F544EE3C8208DD634D4B46303BA
作者：

Dzavakwa, Nyasha, V^[1,2];Simms, Victoria^[1,2]Gregson, Celia L.^[1,3]Chisenga, Molly^[4];Filteau, Suzanne^[5]Kasonka, Lackson^[4];Kranzer, Katharina^[1,6,7]BandaMabuda, Hildah^[4];Mujuru, Hilda^[8];Redzo, Nicol^[1,2];MukwasiKahari, Cynthia^[1,2];RowlandJones, Sarah L.^[9]Schaible, Ulrich E.^[10,11]Ferrand, Rashida A.^[1,7]
语种：

英文
期刊：

OPEN FORUM INFECTIOUS DISEASES ISSN：2328-8957 2024 年 11 卷 9 期 ; SEP 19
疾病分类：

艾滋病
关键词：

adolescent bone density HIV musculoskeletal health vitamin d
摘要：

Background Stunting and pubertal delay are common among children growing up with human immunodeficiency virus (HIV) and are associated with bone and muscle impairments. We investigated factors associated with bone density and muscle function in adolescents living with HIV (ALWH).Methods The VITALITY trial (PACTR202009897660297) investigated whether vitamin D and calcium supplementation improves musculoskeletal health among ALWH. A total of 842 ALWH aged 11-19 years, established on antiretroviral therapy (ART) for >= 6 months, were enrolled from HIV clinics in Zambia and Zimbabwe. Clinical history and examination were undertaken, and serum 25-hydroxyvitamin D3 (25[OH]D3) was measured. Dual-energy X-ray absorptiometry measured total-body-less-head bone mineral density adjusted for height (TBLH-BMDHT), and lumbar spine bone mineral apparent density (LS-BMAD) z scores. The association between a priori-defined covariates and musculoskeletal outcomes were investigated using baseline enrollment data and multivariable logistic regression.Results TBLH-BMDHT z scores were impaired (mean, -1.42 for male and -0.63 female participants), as were LS-BMAD z scores (mean -1.15 for male and -0.47 for female participants). In bivariate analysis, early pubertal stage, less physical activity, and older age at ART initiation were associated with lower TBLH-BMDHT z scores. Younger age, early pubertal stage, and low socioeconomic status were associated with lower LS-BMAD z scores. Grip-strength-for-height and jump-power-for-height z scores were associated with lower TBLH-BMDHT and LS-BMAD z scores. Low dietary vitamin D and calcium were associated with lower adjusted TBLH-BMDHT z scores. Lower 25(OH)D3 was associated with lower adjusted TBLH-BMDHT and LS-BMAD z scores.Conclusions Deficits in bone density are common in ALWH. Vitamin D and calcium supplementation and promotion of exercise may improve musculoskeletal health among perinatally infected ALWH. Adolescents with human immunodeficiency virus in urban Zimbabwe and Zambia have bone mineral density deficit, associated with low levels of both reported dietary vitamin D intake and measured serum 25-hydroxyvitamin D3. Supplementation may improve musculoskeletal health in this group.
推荐引用方式
GB/T 7714：

Dzavakwa Nyasha V,Simms Victoria,Gregson Celia L., et al. Association Between Vitamin D Insufficiency and Impaired Bone Density Among Adolescents With Perinatally Acquired HIV Infection [J].OPEN FORUM INFECTIOUS DISEASES,2024,11(9).
APA：

Dzavakwa Nyasha V,Simms Victoria,Gregson Celia L.,Chisenga Molly,&Ferrand Rashida A..(2024).Association Between Vitamin D Insufficiency and Impaired Bone Density Among Adolescents With Perinatally Acquired HIV Infection .OPEN FORUM INFECTIOUS DISEASES,11(9).
MLA：

Dzavakwa Nyasha V, et al. "Association Between Vitamin D Insufficiency and Impaired Bone Density Among Adolescents With Perinatally Acquired HIV Infection" .OPEN FORUM INFECTIOUS DISEASES 11,9(2024).
数据来源自科睿唯安Web of Science核心合集
入库时间：

2024/10/25 9:54:10
更新时间：

2024/10/25 9:54:10

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