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Field laboratory comparison of STANDARD Q Filariasis Antigen Test (QFAT) with Bioline Filariasis Test Strip (FTS) for the detection of Lymphatic Filariasis in Samoa, 2023 期刊论文

编号：

39412C916ADD0E2BF63A38D998DA31EF
作者：

Scott, Jessica L.^[1] Mayfield, Helen J.^[2,3] Sinclair, Jane E.^[4] Martin, Beatris Mario^[2,3] Howlett, Maddison^[2] Muttucumaru, Ramona^[2,5] Won, Kimberly Y.^[6] Thomsen, Robert^[7] Viali, Satupaitea^[8,9] TofaeonoPifeleti, Rossana^[8] Graves, Patricia M.^[1] Lau, Colleen L.^[2,3]
语种：

英文
期刊：

PLOS NEGLECTED TROPICAL DISEASES ISSN：1935-2735 2024 年 18 卷 8 期 ; AUG
疾病分类：

丝虫病
摘要：

Background To monitor the progress of lymphatic filariasis (LF) elimination programmes, field surveys to assess filarial antigen (Ag) prevalence require access to reliable, user-friendly rapid diagnostic tests. We aimed to evaluate the performance of the new Q Filariasis Antigen Test (QFAT) with the currently recommended Filariasis Test Strip (FTS) for detecting the Ag of Wuchereria bancrofti, the causative agent of LF, under field laboratory conditions. Methodology/Principal findings During an LF survey in Samoa, 344 finger-prick blood samples were tested using FTS and QFAT. Microfilariae (Mf) status was determined from blood slides prepared from any sample that reported Ag-positive by either Ag-test. Each test was re-read at 1 hour and the next day to determine the stability of results over time. Overall Ag-positivity by FTS was 29.0% and 30.2% by QFAT. Concordance between the two tests was 93.6% (kappa = 0.85). Of the 101 Mf slides available, 39.6% were Mf-positive, and all were Ag-positive by both tests. Darker test line intensities from Ag-positive FTS were found to predict Mf-positivity (compared to same/lighter line intensities). QFAT had significantly higher reported test result changes than FTS, mostly reported the next day, but fewer changes were reported between 10 minutes to 1hour. The field laboratory team preferred QFAT over FTS due to the smaller blood volume required, better usability, and easier readability. Conclusion/Significance QFAT could be a suitable and user-friendly diagnostic alternative for use in the monitoring and surveillance of LF in field surveys based on its similar performance to FTS under field laboratory conditions.
推荐引用方式
GB/T 7714：

Scott Jessica L.,Mayfield Helen J.,Sinclair Jane E., et al. Field laboratory comparison of STANDARD Q Filariasis Antigen Test (QFAT) with Bioline Filariasis Test Strip (FTS) for the detection of Lymphatic Filariasis in Samoa, 2023 [J].PLOS NEGLECTED TROPICAL DISEASES,2024,18(8).
APA：

Scott Jessica L.,Mayfield Helen J.,Sinclair Jane E.,Martin Beatris Mario,&Lau Colleen L..(2024).Field laboratory comparison of STANDARD Q Filariasis Antigen Test (QFAT) with Bioline Filariasis Test Strip (FTS) for the detection of Lymphatic Filariasis in Samoa, 2023 .PLOS NEGLECTED TROPICAL DISEASES,18(8).
MLA：

Scott Jessica L., et al. "Field laboratory comparison of STANDARD Q Filariasis Antigen Test (QFAT) with Bioline Filariasis Test Strip (FTS) for the detection of Lymphatic Filariasis in Samoa, 2023" .PLOS NEGLECTED TROPICAL DISEASES 18,8(2024).
数据来源自科睿唯安Web of Science核心合集
入库时间：

2025/3/11 16:14:29
更新时间：

2025/3/11 16:14:29

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