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Determination of T cell response against XBB variants in adults who received either monovalent wild-type inactivated whole virus or mRNA vaccine or bivalent WT/BA.4-5 COVID-19 mRNA vaccine as the additional booster 期刊论文

编号：

2C2C1987E30779B0DB81BB1C47B065D0
作者：

Tang, Yun Sang^[1,2];Tan, Chee Wah^[3,4]Chong, Ka Chun^[1,5]Chen, Chunke^[1,2];Sun, Yuanxin^[1,2];Yiu, Karen^[6];Ling, Kwun Cheung^[6];Chan, Ken K. P.^[2,6];Peiris, Malik(裴伟士)^[7,8]Mok, Chris Ka Pun^[1,2,9,10];Hui, David S.(许树昌)^[6,9]
语种：

英文
期刊：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES ISSN：1201-9712 2024 年 149 卷 ; DEC
疾病分类：

新型冠状病毒肺炎
关键词：

COVID-19 Vaccine Cross-reactive T cell response Bivalent vaccine XBB
摘要：

Objectives: As the SARS-CoV-2 virus evolves more rapidly than vaccines are updated, T cell immunity potentially confers protection against disease progression and death from new variants. In this study, we aimed to assess whether the current boosting vaccination schemes offer sufficient T cell protection against new SARS-CoV-2 variants. Methods: A total of 292 adults who had received the second booster of either monovalent wild-type (WT) vaccines (inactivated virus or mRNA) (Cohort 1) or the second/third booster of bivalent WT/BA.4-5 mRNA vaccine (Cohort 2) were recruited in Hong Kong. All participants showed no serological evidence of recent infection of SARS-CoV-2. Blood samples of each participant were collected before and 1 month after receiving the booster. T cell and antibody responses were determined by flow cytometry and neutralization test, respectively. Results: Among all vaccination strategies, only the adults who had received the bivalent vaccine as the third booster dose significantly elicited T cell responses to the XBB variant. Either monovalent or bivalent mRNA but not inactivated virus vaccine as the second/third booster induced antibody against different XBB variants. Conclusion: Receiving bivalent mRNA vaccine as the third booster is preferable to induce both T cell and antibody responses against XBB. (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
推荐引用方式
GB/T 7714：

Tang Yun Sang,Tan Chee Wah,Chong Ka Chun, et al. Determination of T cell response against XBB variants in adults who received either monovalent wild-type inactivated whole virus or mRNA vaccine or bivalent WT/BA.4-5 COVID-19 mRNA vaccine as the additional booster [J].INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES,2024,149.
APA：

Tang Yun Sang,Tan Chee Wah,Chong Ka Chun,Chen Chunke,&Hui David S..(2024).Determination of T cell response against XBB variants in adults who received either monovalent wild-type inactivated whole virus or mRNA vaccine or bivalent WT/BA.4-5 COVID-19 mRNA vaccine as the additional booster .INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES,149.
MLA：

Tang Yun Sang, et al. "Determination of T cell response against XBB variants in adults who received either monovalent wild-type inactivated whole virus or mRNA vaccine or bivalent WT/BA.4-5 COVID-19 mRNA vaccine as the additional booster" .INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 149(2024).
数据来源自科睿唯安Web of Science核心合集
入库时间：

2025/2/5 16:20:52
更新时间：

2025/2/5 16:20:52

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