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New WHO guidelines for treating rhodesiense human African trypanosomiasis: expanded indications for fexinidazole and pentamidine 期刊论文

编号：

27442A0B915BC4C64E4488B2CBCB898B
作者：

Lindner, Andreas K.^[1] Lejon, Veerle^[2] Barrett, Michael P.^[3] Blumberg, Lucille^[4] Bukachi, Salome A.^[5,6] Chancey, Rebecca J.^[7] Edielu, Andrew^[8,9] Matemba, Lucas^[10] Mesha, Tihitina^[11] Mwanakasale, Victor^[12] Pasi, Christopher^[13] Phiri, Tapunda^[16] Seixas, Jorge^[14,15] Akl, Elie A.^[17,18] Probyn, Katrin^[19] Villanueva, Gemma^[19] Simarro, Pere P.^[20] Ebeja, Augustin Kadima^[21] Franco, Jose R.^[22] Priotto, Gerardo^[22]
语种：

英文
期刊：

LANCET INFECTIOUS DISEASES ISSN：1473-3099 2025 年 25 卷 2 期 ; FEB
关键词：

goencephalitic stage. In contrast rhodesiense HAT International Health Berlin
摘要：

Human African trypanosomiasis is a neglected tropical disease that is usually fatal without treatment. WHO has revised its rhodesiense human African trypanosomiasis treatment guidelines on the basis of an independent systematic literature review and following the GRADE methodology. This Review reports on the decision-making process and summarises the new recommendations and their potential implications for health-care professionals and policy makers. Due to data scarcity, all recommendations are conditional and based on very low certainty of evidence. Fexinidazole replaces suramin and melarsoprol as the first-line therapy in individuals aged 6 years and older with a bodyweight of 20 kg or more. As fexinidazole is effective in both stages of rhodesiense human African trypanosomiasis, a lumbar puncture for staging is no longer required. In settings in which first-choice drugs are not readily available, immediate interim treatment with pentamidine is suggested. The introduction of oral fexinidazole represents an advancement in the management of rhodesiense human African trypanosomiasis considering the life- threatening adverse reactions individuals can have to melarsoprol. However, children below the age or weight limits remain ineligible for treatment with fexinidazole.
推荐引用方式
GB/T 7714：

Lindner Andreas K.,Lejon Veerle,Barrett Michael P., et al. New WHO guidelines for treating rhodesiense human African trypanosomiasis: expanded indications for fexinidazole and pentamidine [J].LANCET INFECTIOUS DISEASES,2025,25(2).
APA：

Lindner Andreas K.,Lejon Veerle,Barrett Michael P.,Blumberg Lucille,&Priotto Gerardo.(2025).New WHO guidelines for treating rhodesiense human African trypanosomiasis: expanded indications for fexinidazole and pentamidine .LANCET INFECTIOUS DISEASES,25(2).
MLA：

Lindner Andreas K., et al. "New WHO guidelines for treating rhodesiense human African trypanosomiasis: expanded indications for fexinidazole and pentamidine" .LANCET INFECTIOUS DISEASES 25,2(2025).
数据来源自科睿唯安Web of Science核心合集
入库时间：

2025/4/6 16:41:34
更新时间：

2025/4/6 16:41:34

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