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Cigarette smoke compromises macrophage innate sensing in response to pneumococcal infection 期刊论文

编号：

18703C6EEA41B5435D7F9F3056A23D5A
作者：

Liao, WeiChih^[1,2,3] Chou, ChiaHuei^[3,4] Ho, MaoWang^[3,4] Chen, JoTsen^[5,6] Chou, ShuLing^[7] Huang, YuTsen^[5] Bui, NgocNiem^[5,8] Wu, HuiYu^[5] Lee, ChiFan^[9] Huang, WeiChien^[9,10] Lai, ChihHo^{[3,5,6,11,12]}
语种：

英文
期刊：

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION ISSN：1684-1182 2025 年 58 卷 1 期 (120 - 127) ; FEB
关键词：

Cigarette smoke Pneumococcus Macrophage Cytokine Inflammation
摘要：

Background: Cigarette smoking remains a leading cause of mortality worldwide. Streptococcus pneumoniae, also known as pneumococcus, is one of the most common pathogens that colonizes the human respiratory tract, causing life-threatening infections. Several studies have reported that cigarette smoke (CS) exposure promotes pneumococcal infectivity; however, the underlying mechanisms remain to be illustrated. Methods: In this study, we prepared cigarette smoke extract (CSE) from tobacco containing nicotine (0.8 mg/ cigarette) and tar (10 mg/cigarette) to investigate the effects of CSE on innate immune response using murine macrophage models. Results: The results from the cytokine array showed that the production of C-C Motif Chemokine Ligand 2 (CCL2), CCL4, CCL3, C-X-C Motif Chemokine Ligand 2 (CXCL2), and CXCL-10, in pneumococcus-infected cells was reduced upon 5 % CSE treatment. Our results further demonstrated that 5 % CSE exposure, followed by pneumococcal challenge, significantly decreased CCL2 and type I interferon (IFN) production in macrophages by inhibiting nuclear factor (NF)-kappa B and IFN regulatory factor 3 (IRF3) signaling pathways. Moreover, CSE disrupts macrophage polarization and impedes innate immune signaling to suppress pneumococcal phagocytosis by macrophages. Conclusion: Our results provide evidence that CS manipulates the signaling molecules to subvert macrophage functions, thereby hindering the innate response against pneumococcal infection.
推荐引用方式
GB/T 7714：

Liao Wei-Chih,Chou Chia-Huei,Ho Mao-Wang, et al. Cigarette smoke compromises macrophage innate sensing in response to pneumococcal infection [J].JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION,2025,58(1):120-127.
APA：

Liao Wei-Chih,Chou Chia-Huei,Ho Mao-Wang,Chen Jo-Tsen,&Lai Chih-Ho.(2025).Cigarette smoke compromises macrophage innate sensing in response to pneumococcal infection .JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION,58(1):120-127.
MLA：

Liao Wei-Chih, et al. "Cigarette smoke compromises macrophage innate sensing in response to pneumococcal infection" .JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION 58,1(2025):120-127.
数据来源自科睿唯安Web of Science核心合集
入库时间：

2025/3/11 16:09:55
更新时间：

2025/3/11 16:09:55

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