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Scale-up of 99DOTS for TB treatment supervision: an interrupted time series analysis 期刊论文

编号：

0C1716F26B5F56D37F64F5001B1657F7
作者：

Crowder, R.^[1,2] Nakasendwa, S.^[3] Kityamuwesi, A.^[3] Musoke, M.^[3] Nannozi, J.^[3] Waswa, J.^[3] Sanyu, A. N.^[3] Lamunu, M.^[3] Twinamasiko, A.^[3] Tinka, L. K.^[3] Oyuku, D.^[3] Babirye, D.^[3] Berger, C.^[1,2] Thompson, R.^[4] Turyahabwe, S.^[5] Dowdy, D.^[3,4] Katamba, A.^[3,6] Cattamanchi, A.^[1,2,3,7] Kiwanuka, N.^[3,8]
语种：

英文
期刊：

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE ISSN：1027-3719 2025 年 29 卷 7 期 (306 - 311) ; JUN 27
疾病分类：

肺结核PTB
关键词：

tuberculosis Uganda digital adherence technology
摘要：

B A C K G R O U N D : Digital adherence technologies such as 99DOTS are being scaled-up for TB treatment despite limited evidence of their effectiveness and concerns about accessibility. We evaluated the reach and effectiveness of 99DOTS during its scale-up in Uganda. M E T H O D S : We included all adults initiating drug2019 to June 2021 at 12 99DOTS-na & imath;ve health facilities (n 1/4 3,526). Using an interrupted time series design, we compared the proportion with treatment success (primary outcome) and enrolled on 99DOTS in the 9 months before and 12 months after implementing an ''enhanced 99DOTS'' intervention. This included providing low-cost phones to people with TB when needed, task shifting monitoring and support to community health workers, and automated task lists. Treatment data were derived from routine TB treatment registers. RESULTS: The proportion enrolled on 99DOTS post-intervention was high (87.2%) and had a slight upward trend (proportion ratio 1.01, 95% CI 1.00-1.01). Treatment completion remained similar across periods (89.8% post-intervention vs. 87.1% pre-intervention). There was no immediate level or slope change in treatment success following the intervention. CON C L U SIO N S : With appropriate implementation supports, 99DOTS can have high uptake without negatively impacting treatment outcomes. Equity in access should be prioritized during implementation.
推荐引用方式
GB/T 7714：

Crowder R.,Nakasendwa S.,Kityamuwesi A., et al. Scale-up of 99DOTS for TB treatment supervision: an interrupted time series analysis [J].INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE,2025,29(7):306-311.
APA：

Crowder R.,Nakasendwa S.,Kityamuwesi A.,Musoke M.,&Kiwanuka N..(2025).Scale-up of 99DOTS for TB treatment supervision: an interrupted time series analysis .INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE,29(7):306-311.
MLA：

Crowder R., et al. "Scale-up of 99DOTS for TB treatment supervision: an interrupted time series analysis" .INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 29,7(2025):306-311.
数据来源自科睿唯安Web of Science核心合集
入库时间：

2025/8/27 11:36:10
更新时间：

2025/8/27 11:36:10

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