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Artemisinin displays bactericidal activity via copper-mediated DNA damage 期刊论文

编号：

0AAFDF95D9D1DE33703656046FB47D66
作者：

Chung, InYoung Jang, HyeJeong Yoo, YeonJi Hur, Joonseong Oh, HyoYoung Kim, SeokHo Cho, YouHee^[1]
语种：

英文
期刊：

VIRULENCE ISSN：2150-5594 2022 年 13 卷 1 期 (149 - 159) ; DEC 31
疾病分类：

霍乱
关键词：

Artemisinin antimalarial antibacterial copper Vibrio cholerae
摘要：

Artemisinin (ARS) and its semi-synthetic derivatives are effective drugs to treat malaria and possess multiple therapeutic activities based on their endoperoxide bridge. Here, we showed that ARS displayed antibacterial efficacy in Drosophila systemic infections caused by bacterial pathogens but killed only Vibrio cholerae (VC) in vitro, involving reactive oxygen species (ROS) generation and/or DNA damage. This selective antibacterial activity of ARS was attributed to the higher intracellular copper levels in VC, in that the antibacterial activity was observed in vitro upon addition of cuprous ions even against other bacteria and was compromised by the copper-specific chelators neocuproine (NC) and triethylenetetramine (TETA) in vitro and in vivo. We suggest that copper can enhance or reinforce the therapeutic activities of ARS to be repurposed as an antibacterial drug for the treatment of bacterial infections.
推荐引用方式
GB/T 7714：

Chung In-Young,Jang Hye-Jeong,Yoo Yeon-Ji, et al. Artemisinin displays bactericidal activity via copper-mediated DNA damage [J].VIRULENCE,2022,13(1):149-159.
APA：

Chung In-Young,Jang Hye-Jeong,Yoo Yeon-Ji,Hur Joonseong,&Cho You-Hee.(2022).Artemisinin displays bactericidal activity via copper-mediated DNA damage .VIRULENCE,13(1):149-159.
MLA：

Chung In-Young, et al. "Artemisinin displays bactericidal activity via copper-mediated DNA damage" .VIRULENCE 13,1(2022):149-159.
数据来源自科睿唯安Web of Science核心合集
入库时间：

2022/2/13 0:10:24
更新时间：

2022/2/13 0:10:24

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